Responses of thoracic spinothalamic neurons to intracardiac injection of bradykinin in the monkey.

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Responses of thoracic spinothalamic neurons to intracardiac injection of bradykinin in the monkey.

Bradykinin stimulates afferent fibers arising in the heart and may be involved in the mediation of anginal pain and the pain associated with myocardial infarction. The sensation of pain requires that noxious information reach the brain. The purpose of the present study was to determine whether the spinothalamic tract is involved in transmitting noxious information from the heart to the brain. B...

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Vagal afferent inhibition of spinothalamic cell responses to sympathetic afferents and bradykinin in the monkey.

Effects of stimulating the left thoracic vagus nerve on the responses of spinothalamic neurons to electrical stimulation of cardiopulmonary sympathetic afferent fibers and to intracardiac injections of bradykinin were determined. Experiments were performed on 39 monkeys (Macaca fascicularis) tranquilized with ketamine and anesthetized with alpha-chloralose. The 30 spinothalamic cells studied ha...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1982

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.51.1.83